How to Minimize Powder Segregation in Sachet Filling Machines?
Assuming that a production batch of oral powder sachets was prepared using a dry mixing method. Post-preparation, a uniformity test for API was conducted, and the results were Satisfactory.
Subsequently, the product was filled into sachets using a sachet filling machine. A content uniformity test was then performed, yielding non-conforming results. The root cause was identified as segregation.
Segregation during sachet filling can lead to inconsistent doses, affecting product quality. Here are some practical tips to reduce segregation and ensure uniformity in each sachet:
Control Particle Size
- Ensure the powder mix has uniform particle sizes to prevent separation. Granulating the powder can also help reduce segregation.
Reduce Machine Vibration
- Stabilize the machine with vibration-dampening mounts and operate at a controlled speed to minimize particle movement during filling.
Improve Powder Flow Properties
- Add flow aids like glidants “Aerosil 200 to improve flowability, ensuring the powder moves consistently through the machine.
Optimize Hopper Design
- Use hoppers designed for mass flow, which ensure all particles move together, and consider using low-intensity agitators to avoid stratification.
Control Airflow
- Minimize air introduction during filling to prevent lighter particles from separating, and avoid turbulent airflows.
Use Dosing Augers
- Auger filling systems provide precise control over the powder flow, ensuring consistent amounts are filled into each sachet.
Monitor the Process
- Regularly check sachets for content uniformity and adjust machine parameters if any segregation issues arise.
By implementing these practices, we can ensure every sachet delivers a consistent and high-quality product.
Read also:
Resource Person: Jamal Jameel
