pKa

The pKa of a drug substance plays a crucial role in excipient selection during formulation development. pKa is the measure of the acidity or basicity of a molecule, indicating the pH at which half of the drug exists in its ionized form. Since ionization affects solubility, stability, and permeability, understanding pKa helps formulators choose excipients…

The pKa and dissolution constant of an Active Pharmaceutical Ingredient (API) are fundamental properties in formulation development. Together, they determine how the drug behaves in different pH environments, influences its bioavailability, absorption, stability, and ultimately its therapeutic effectiveness. Here’s how they work in synergy: Solubility and Dissolution Rate: The dissolution constant indicates the rate at…