Coating solution is about two things When we say the concentration of the coating solution is 10%, what does it mean? How do I know how to calculate the amount of solution based on the amount of tablets? For example, you have a 1000 mg tablet and you want to add 50 mg…
Active coating means a coating solution that contains an active substance. Here we must know why the active substance is placed in a coating solution? In order for the effect of the active substance to be rapid, even if it is placed inside the core, it will not achieve what is required of it. Thus,…
In this post, we will know what the difference between AQUEOUS and NON-AQUEOUS film coating. First, we must know why we use aqueous, why we use non-aqueous, and why we do not use one type of for all products. Comparison between the two types in the process: Some notes Read also: Resource Person:…
Coating machines are divided into two types Basically, the coating process depends on 3 basic elements: Firstly, Temperature There are two very important components in any coating machines: There are two fans, one responsible for entering air into the machine (inlet air fan), and before it is a HEPA filter to purify the…
In tableting the compaction force is a crucial parameter that is a major driver for the final product’s properties. But its influence varies across different characteristics: 1. Weight and Weight Uniformity: In general, the weight of tablets remains unchanged by compaction force, ensuring dosage consistency but on rotary tablet presses the weight uniformity sometimes…
In tablet manufacturing, keeping active ingredients and excipients together requires sufficiently large bonding forces between the various particles. During development, we explore the bonding capacity of pure APIs, excipients, and formulations for developing and improving formulations. This is done by performing compaction trials for determining compatibility profiles according to USP 1062. But what keeps…
There are three stages involved in this cycle: 1) Filling stage At the filling stage you have to adjust the lower punch to die for which fill depth setting needs to be done in such a way that required powder only gets filled to maintain the tablet weight. So this part becomes very important…
This time we focus on a drug manufacturing facility in South Korea, issued a Warning Letter on June 12, 2024 Inadequate Validation of Manufacturing Processes The facility failed to adequately validate manufacturing processes for their over-the-counter (OTC) drug product. This includes insufficient data to demonstrate process validation and equipment qualification. Corrective Actions –…
