Why pH of Pharmaceutical Solutions Changes by Holding Time?
1. Degradative effects of Active Pharmaceutical ingredients which may be: e.g. Epinephrine in solution undergoes racemization and oxidation, but if the pH is maintained at 3.0 or lower, little reaction occurs. Atropine sulfate rapidly hydrolyzes in solution, but if the pH is maintained with a buffer system at about 3.5 to 4.0 ,hydrolysis does not…