pH

Why pH of Pharmaceutical Solutions Changes by Holding Time?

Why pH of Pharmaceutical Solutions Changes by Holding Time?

1. Degradative effects of Active Pharmaceutical ingredients which may be: e.g. Epinephrine in solution undergoes racemization and oxidation, but if the pH is maintained at 3.0 or lower, little reaction occurs. Atropine sulfate rapidly hydrolyzes in solution, but if the pH is maintained with a buffer system at about 3.5 to 4.0 ,hydrolysis does not…

Why Do We Do pH in the Pharmaceutical Industry?

Why Do We Do pH in the Pharmaceutical Industry?

pH is a measure of a solution’s acidity or alkalinity. In the pharmaceutical industry, pH is important because it can affect the stability, efficacy, solubility, and bioavailability of drugs:   pH is mesured in the pharmaceutical industry to check/ensure: 1. Drug stability The stability of many drugs is affected by pH.  For example, some drugs…