In pharmaceutical formulation development, finalizing the tablet weight is not a routine or arbitrary decision. It is a strategic choice that can significantly impact bioequivalence outcomes, patient compliance, manufacturing efficiency, and regulatory acceptance. This decision is influenced by multiple factors. Here’s how development teams typically approach it: Innovator (RLD) Tablet Weight as a Benchmark The…
Fillers in tableting Strictly speaking, fillers should only fill up the missing tablet mass and be as inert as possible. This means that they should not interact with the API or other necessary excipients. Functional fillers However, it makes no sense to add inert substances which are non-binding or have no other functionality. That’s why…
In tablet manufacturing, keeping active ingredients and excipients together requires sufficiently large bonding forces between the various particles. During development, we explore the bonding capacity of pure APIs, excipients, and formulations for developing and improving formulations. This is done by performing compaction trials for determining compatibility profiles according to USP 1062. But what keeps…
There are three stages involved in this cycle: 1) Filling stage At the filling stage you have to adjust the lower punch to die for which fill depth setting needs to be done in such a way that required powder only gets filled to maintain the tablet weight. So this part becomes very important…
 Description of the problem: Corrosion and irregularity in the edges of the tablets . Reasons: 1: fine powder. 2: The punches are worn out. 3: The moisture of the powder is low. 4: Hardness is low. 5: The distribution of powder is uneven . 6: Separating the powder in the hopper or while using…
Type B Type D Read also: Points to be Considered When Purchasing Tablet Punches and Dies Tablet Tooling in Pharmaceutical Industry Resource Person: Ali Saleh Ali
With more and more washing of the pan and the use of cleaning materials and drying and also with the old age and too much using the machine, the stainless steel of the pan is affected and may interact with the tablets . Now some brands of coating machines have begun to fix this problem…
1) Raw material sourcing and testing The raw materials for tablet manufacturing are typically sourced from approved suppliers who have been vetted for quality and reliability. The raw materials are tested for quality and purity before being used in the manufacturing process. This is to ensure that the tablets are safe and effective. 2)…
