To make the effervescent reaction happening a carbonate component and an acid are required. In the presence of water, carbon dioxide is formed, and the tablet disintegrates. This leads to the typical bubbling. Effervescent tablets have a separate monograph in the pharmacopoeia which e.g., limits the disintegration time. Typical Excipients Disadvantages of Effervescent Tablets Effervescent…
Another group of excipients in solid dosage forms are the so-called water penetration enhancers. How They Work They do not have any disintegration effect themselves but assist water to penetrate the tablet. As a result, water can reach the particles of the disintegrants better, and these can therefore develop their effect more quickly. Which means…
Fillers in tableting Strictly speaking, fillers should only fill up the missing tablet mass and be as inert as possible. This means that they should not interact with the API or other necessary excipients. Functional fillers However, it makes no sense to add inert substances which are non-binding or have no other functionality. That’s why…
