Granulation

Selecting the right processing platform for solid dosage forms is essential for ensuring product quality, efficacy, and manufacturability. This decision-guiding flowchart provides a structured approach to choosing the best processing method based on key formulation parameters. Key Considerations: 1. Solubility: The Biopharmaceutics Classification System (BCS) class determines solubility. For Class II & IV compounds, solubility…

At low moisture levels, termed the (pendular state), the particles are held together by lens-shaped rings of liquid. These cause adhesion because of the surface tension forces of the liquid-air interface and the hydrostatic suction pressure in the liquid bridge. When all the air has been displaced from between the particles, the (capillary state) is…