Factors Affecting Tablet Compression
Tablet compression is a complex process influenced by multiple critical factors, including:
Material Properties: Particle size, shape, flowability, and moisture content of the powder blend
Compression Force: Magnitude and duration of pressure applied by the punches
Lubrication: Type and amount of lubricant used to reduce friction and prevent sticking
Die & Tooling: Surface finish, clearance, and wear of punches and die
Machine Design: Configuration and alignment of tablet press components
Compression Speed: Rate at which punches move during the compression cycle
Pre-compression: Application of initial low pressure before the main compression
Each factor plays a vital role in ensuring tablet quality, uniformity, and production efficiency. A thorough understanding of these elements is key to successful tablet formulation and manufacturing.
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