At first glance, most people assume capsules always contain powder — but have you ever wondered why some are filled with liquid? Let’s break it down! Capsules generally come in two types: But why use liquid at all? Enhanced Absorption: Some drugs dissolve better in oil or other liquids, making them more bioavailable (faster and…
For a direct compression (DC)-based formulation to succeed, it demands strategic selection of excipients, API characterization, and continuous optimization based on product performance data. Below is a stepwise, flowchart-based approach to Direct Compression development 1. Evaluate the API These properties directly affect blend selection and performance. Example: If the API constitutes 30% w/w of the…
What is Viscosity? Viscosity measures a fluid’s resistance to flow, determining how easily it deforms under an applied force. High-viscosity fluids like honey flow slowly, while low-viscosity fluids like water flow quickly. Viscosity is temperature-dependent, generally decreasing as the fluid warms. It’s measured in units such as poise (P) or pascal-seconds (Pa·s). Types of Viscosity:…
Karl Fischer (KF) titration is a widely used method for moisture determination in various industries, including pharmaceuticals, chemicals, and food production. One crucial factor that ensures the accuracy and reliability of KF titration is the use of dried methanol as a solvent. But why is this so important? Let’s dive into the details. 1. Water-Free…
Weigh a clean & dry volumetric flask. Calibrate the flask by filling it with recently boiled and cooled distilled water at room temperature up to the mark and weigh the flask. Determine the volume in ml by the formula; Volume (in ml) = (Weight in g / 0.99602)Where, 0.99602 g is the weight of 1…
1. Distilled Water This is produced by vaporizing water and condensing it in a purer state. It is mainly used for preparing reagents but may also be required for other laboratory operations such as rinsing an analyte, transferring a test material as a slurry, as a calibration standard or analytical blank and for cleaning of…
HPLC (High-Performance Liquid Chromatography) and UHPLC (Ultra-High Performance Liquid Chromatography) are both powerful techniques used in chemical analysis, but there are some key differences between them: Pressure and Particle Size: Speed and Efficiency: Applications: Cost and Maintenance: Personal Experience with Waters and Agilent Systems I’ve worked with three systems so far: Waters, Agilent 1290, and…
In the pharmaceutical industry, a crossover bench in a clean room serves as an essential piece of equipment to maintain cleanliness and prevent cross-contamination. The primary purposes of the crossover bench include: Preventing Contamination Between Zones: Clean rooms in pharmaceutical settings are typically divided into various zones with different levels of cleanliness. A crossover bench…
