In tableting the compaction force is a crucial parameter that is a major driver for the final product’s properties. But its influence varies across different characteristics: 1. Weight and Weight Uniformity: In general, the weight of tablets remains unchanged by compaction force, ensuring dosage consistency but on rotary tablet presses the weight uniformity sometimes…
In tablet manufacturing, keeping active ingredients and excipients together requires sufficiently large bonding forces between the various particles. During development, we explore the bonding capacity of pure APIs, excipients, and formulations for developing and improving formulations. This is done by performing compaction trials for determining compatibility profiles according to USP 1062. But what keeps…
There are three stages involved in this cycle: 1) Filling stage At the filling stage you have to adjust the lower punch to die for which fill depth setting needs to be done in such a way that required powder only gets filled to maintain the tablet weight. So this part becomes very important…
What is the description of the problem? The presence of pits and irregularities at the top of the tablets surface due to the increased porosity of the tablets surface and the penetration of the coating solution into it. What are the reasons? Are the reasons related only to the coating stage or are there…
1) Raw material sourcing and testing The raw materials for tablet manufacturing are typically sourced from approved suppliers who have been vetted for quality and reliability. The raw materials are tested for quality and purity before being used in the manufacturing process. This is to ensure that the tablets are safe and effective. 2)…
Pharmaceutical tablets must meet their physical specifications and quality standards for ensuring safety and efficacy. These include weight variation, content uniformity, hardness, thickness, friability, disintegration, and dissolution. These factors must be controlled during production (in-process controls) and verified after the production of each batch to ensure that established product quality standards are met. Weight…
Tablet is the most common and convenient dosage form. Itcontains active ingredient(s) and excipients. The various types of tablets aredescribed as follows: Compressed Tablets In addition to the API(s), compressed tablets usuallycontain a number of pharmaceutical excipients, including diluents or fillers, bindersor adhesives, disintegrants or disintegrating agents, anti-adherents, glidants,and lubricants to prepare the tablets of…
To ensure the quality of the drugs produced, strict guidelines and regulations shall be in place and followed by the pharmaceutical companies. What are Good Manufacturing Practices Violations? GMP stands for Good Manufacturing Practices and it is a set of regulations that must be followed when manufacturing pharmaceuticals. There are a few different types…
