Effect of Granule Particle Size on Dissolution of BCS Class 2 & 4 Drugs
Granule particle size plays a pivotal role in drug dissolution, especially for BCS Class 2 (low solubility, high permeability) and BCS Class 4 (low solubility, low permeability) drugs. Here’s how:
Key Factors to Consider:
1. Surface Area vs. Dissolution Rate:
- Smaller granules offer a higher surface area, enhancing dissolution rates significantly—crucial for poorly soluble drugs.
- Larger granules may slow down dissolution but provide better flowability during processing.
2. Porosity and Wetting:
- Smaller particles improve granule porosity and wetting, ensuring faster penetration of dissolution media.
- However, excessive reduction in particle size can lead to poor compressibility.
3. Granule Size Distribution:
- Uniform size distribution minimizes variability in dissolution profiles.
- Tailoring particle size to achieve the ideal dissolution rate without compromising stability is vital.
Why It Matters for BCS Class 2 & 4 Drugs?
- For BCS Class 2 drugs, enhancing solubility through controlled particle size improves absorption and bioavailability.
- For BCS Class 4 drugs, achieving optimal dissolution is key to overcoming dual challenges of low solubility and permeability.
The right granule size can transform challenges into opportunities for better therapeutic outcomes!
Read also:
- Micromeritics
- Impact of Surface Area on Dissolution
- Particle Size Reduction in Pharmaceutical Industry
Resource Person: Dev Soni
