When we think of blending APIs and excipients, we think of uniformity, efficiency, and harmony. But what if I told you there’s an invisible force that can ruin your blend even before compression? Yes — Static Electricity. And it’s not just a physics problem. It’s a formulation nightmare. Let’s go deeper Why static charge forms…
The expiry date printed on your medicines isn’t arbitrary—it’s carefully determined through rigorous stability studies to ensure the drug remains safe and effective throughout its shelf life. Here’s a breakdown of how it’s done: Step 1: Stability Studies Pharmaceutical companies test drugs under controlled conditions to monitor: These studies are performed using samples stored under…
Granule particle size plays a pivotal role in drug dissolution, especially for BCS Class 2 (low solubility, high permeability) and BCS Class 4 (low solubility, low permeability) drugs. Here’s how: Key Factors to Consider: 1. Surface Area vs. Dissolution Rate: 2. Porosity and Wetting: 3. Granule Size Distribution: Why It Matters for BCS Class 2…
At first glance, most people assume capsules always contain powder — but have you ever wondered why some are filled with liquid? Let’s break it down! Capsules generally come in two types: But why use liquid at all? Enhanced Absorption: Some drugs dissolve better in oil or other liquids, making them more bioavailable (faster and…
For a direct compression (DC)-based formulation to succeed, it demands strategic selection of excipients, API characterization, and continuous optimization based on product performance data. Below is a stepwise, flowchart-based approach to Direct Compression development 1. Evaluate the API These properties directly affect blend selection and performance. Example: If the API constitutes 30% w/w of the…
What is Viscosity? Viscosity measures a fluid’s resistance to flow, determining how easily it deforms under an applied force. High-viscosity fluids like honey flow slowly, while low-viscosity fluids like water flow quickly. Viscosity is temperature-dependent, generally decreasing as the fluid warms. It’s measured in units such as poise (P) or pascal-seconds (Pa·s). Types of Viscosity:…
Karl Fischer (KF) titration is a widely used method for moisture determination in various industries, including pharmaceuticals, chemicals, and food production. One crucial factor that ensures the accuracy and reliability of KF titration is the use of dried methanol as a solvent. But why is this so important? Let’s dive into the details. 1. Water-Free…
Weigh a clean & dry volumetric flask. Calibrate the flask by filling it with recently boiled and cooled distilled water at room temperature up to the mark and weigh the flask. Determine the volume in ml by the formula; Volume (in ml) = (Weight in g / 0.99602)Where, 0.99602 g is the weight of 1…
